| Home teams listed first |
|---|
| All Times EDT |
| QUARTERFINALS |
| First Leg |
| Tuesday, March 5 |
Houston (United States) 1, Santos Laguna (Mexico) 0
| Wednesday, March 6 |
|---|
Monterrey (Mexico) 3, Xelaju (Guatemala) 1
Tigres (Mexico) 1, Seattle (United States) 0
| Thursday, March 7 |
|---|
Herediano (Costa Rica) 0, LA Galaxy (United States) 0
| Second Leg |
|---|
| Tuesday, March 12 |
Monterrey (Mexico) 1, Xelaju (Guatemala) 1, Monterrey advances on 4-2 aggregate
Seattle (United States) 3, Tigres (Mexico) 1, Seattle advances on 3-2 aggregate
| Wednesday, March 13 |
|---|
Santos Laguna (Mexico) 3, Houston (United States) 0, Santa Laguna advances on 3-1 aggregate
LA Galaxy (United States) 4, Herediano (Costa Rica) 1, LA Galaxy advances on 4-1 aggregate.
